Author

I. Sekler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Physiology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Research Focus:metabolism & bioenergetics· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:imaging· 2

Frequent Co-Authors

E. A. Assali· 2 shared M. Hershfinkel· 2 shared M. Taha· 2 shared O. S. Shirihai· 2 shared A. E. Jones· 1 shared A. Stavsky· 1 shared C. Delierneux· 1 shared D. L. Gill· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPhysiology

E. A. Assali

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

NCLX controls hepatic mitochondrial Ca2+ extrusion and couples hormone-mediated mitochondrial Ca2+ oscillations with gluconeogenesis

M. Taha, E. A. Assali, G. E. Stutzmann, O. S. Shirihai, M. Hershfinkel, I. Sekler

This study identifies NCLX as the primary mitochondrial Ca2+ extruder in hepatocytes, linking hormone-mediated mitochondrial Ca2+ oscillations to gluconeogenesis.

bioRxiv · Feb 9, 2024Physiology

The mitochondrial Na+/Ca2+ exchanger, NCLX, mediates PDE2 dependent neuronal survival and learning

M. Rozenfeld, I. Savic Azoulay, T. Ben Kasus Nissim, A. Stavsky, M. Hershfinkel, O. Kofman, I. Sekler

This study links PDE2 inhibition to mitochondrial Ca2+ efflux via NCLX, enhancing neuronal survival and learning.

bioRxiv · Jul 8, 2021 · PreprintPhysiology

Colorectal adenocarcinomas downregulate the mitochondrial Na+/Ca2+ exchanger NCLX to drive metastatic spread

T. Pathak, M. Gueguinou, V. Walter, C. Delierneux, M. T. Johnson, X. Zhang, P. Xin, R. E. Yoast, S. M. Emrich, G. S. Yochum, I. Sekler, W. A. Koltun, D. L. Gill, N. Hempel, M. Trebak

This study shows that reduced NCLX expression in colorectal tumors leads to mtCa2+ overload, promoting metastasis and chemoresistance through mtROS/HIF1 signaling.

bioRxiv · May 7, 2020 · PreprintCancer Biology

Elucidating the H+ coupled Zn2+ transport mechanism of ZIP4; implications in Acrodermatitis Enteropathica

E. Hoch, I. Sekler

This study investigates ZIP4's function as an H+ coupled Zn2+ co-transporter and links genetic variants to Acrodermatitis Enteropathica.

bioRxiv · Nov 20, 2018Physiology

NCLX prevents cell death during adrenergic activation of the brown adipose tissue

E. A. Assali, A. E. Jones, M. Veliova, M. Taha, N. Miller, M. Shum, M. F. Oliveira, G. Las, M. Liesa, I. Sekler, O. S. Shirihai

This study identifies NCLX as a critical mitochondrial Na+/Ca2+ exchanger that prevents cell death during adrenergic activation of brown adipose tissue by mitigating Ca2+ overload.

bioRxiv · Nov 6, 2018Physiology