Heparan sulfate modifications of betaglycan promote TIMP3-dependent ectodomain shedding to fine-tune TGF-β signaling.
A. S. Choi, L. M. Jenkins-Lane, W. Barton, A. Kumari, C. Lancaster, C. Raulerson, H. Ji, D. Altomare, M. D. Starr, R. Whitaker, R. Phaeton, R. C. Arend, M. Shtutman, A. B. Nixon, N. Hempel, , K. Mythreye
This study identifies heparan sulfate modifications as critical for betaglycan ectodomain shedding, which regulates TGF-β signaling and has clinical implications in ovarian cancer.
bioRxiv · Aug 29, 2023 · PreprintBiochemistry