Author

R. Phaeton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

N. Hempel· 5 shared K. Mythreye· 4 shared N. Y. Lee· 4 shared K. M. Aird· 3 shared A. T. Elhaw· 2 shared D. Altomare· 2 shared M. D. Starr· 2 shared R. C. Arend· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersCancer Biology

N. Hempel

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Author profile →

5 papers

Recent·Most cited

GPX3 supports ovarian cancer tumor progression in vivo and promotes expression of GDF15

C. Chang, Y.-Y. Cheng, S. Kamlapurkar, S. R. White, P. W. Tang, A. T. Elhaw, Z. Javed, K. M. Aird, K. Mythreye, R. Phaeton, N. Hempel

This study shows GPX3 is necessary for ovarian cancer growth in vivo and promotes GDF15 expression, linking it to immune checkpoint inhibitor response.

bioRxiv · Jan 24, 2024Cancer Biology

Alternative splice variants of the mitochondrial fission protein DNM1L/Drp1 regulate mitochondrial dynamics and cell fate in ovarian cancer.

Z. Javed, D. H. Shin, W. Pan, S. R. White, Y. S. Kim, A. T. Elhaw, S. Kamlapurkar, Y.-Y. Cheng, J. C. Benson, A. E. Abdelnaby, R. Phaeton, H.-G. Wang, S. Yang, M. L. G. Sullivan, C. St. Croix, , N. Hempel

This study identifies an alternative splice variant of Drp1 in ovarian cancer that promotes metastasis and chemoresistance by altering mitochondrial dynamics.

bioRxiv · Sep 20, 2023Cancer Biology

Heparan sulfate modifications of betaglycan promote TIMP3-dependent ectodomain shedding to fine-tune TGF-β signaling.

A. S. Choi, L. M. Jenkins-Lane, W. Barton, A. Kumari, C. Lancaster, C. Raulerson, H. Ji, D. Altomare, M. D. Starr, R. Whitaker, R. Phaeton, R. C. Arend, M. Shtutman, A. B. Nixon, N. Hempel, , K. Mythreye

This study identifies heparan sulfate modifications as critical for betaglycan ectodomain shedding, which regulates TGF-β signaling and has clinical implications in ovarian cancer.

bioRxiv · Aug 29, 2023 · PreprintBiochemistry

Reciprocal epigenetic Sox2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer

Z. SHONIBARE, M. Monavarian, K. O'Connell, D. Altomare, A. K. Shelton, S. Mehta, R. Jaskula-Sztul, R. Phaeton, M. D. Starr, R. Whitaker, A. Berchuck, A. Nixon, R. C. Arend, N. Y. Lee, C. R. Miller, , K. Mythreye

This study identifies Sox2 as a key node regulated by opposing TGF-β superfamily signals, impacting anoikis resistance and metastasis in ovarian cancer.

bioRxiv · Jan 11, 2022Cancer Biology

Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.

Y. S. Kim, P. Gupta-Vallur, V. M. Jones, B. L. Worley, S. Shimko, D.-H. Shin, L. C. Crawford, C.-W. Chen, K. M. Aird, T. Abraham, T. G. Shepherd, J. I. Warrick, N. Y. Lee, R. Phaeton, K. Mythreye, N. Hempel

This study shows that SIRT3 activation is required for ovarian cancer cell survival and metastasis by regulating mitochondrial antioxidant defenses and metabolic changes during detachment.

bioRxiv · Jun 13, 2019Cancer Biology