Cancer BiologybioRxiv
Rothmund-Thomson Syndrome-like RECQL4 truncating mutations cause a haploinsufficient low bone mass phenotype in mice
W. Castillo-Tandazo, A. E. Frazier, N. A. Sims…·C. R. Walkley
This study shows that truncating RECQL4 mutations in mice cause low bone mass and reduced cortical bone thickness, highlighting RECQL4 gene dosage as a regulator of bone mass.
DOI 10.1128/mcb.00590-20