Selective BCL-XLAntagonists Eliminate Infected Cells from a Primary Cell Model of HIV Latency but not from Ex Vivo Reservoirs
Y. Ren, s. h. huang, A. Macedo, A. Ward, W. Conce, T. Klevorn, L. Leyre, D. Chan, R. Truong, T. Rohwetter, P. Zumbo, F. Dundar, D. Betel, C. Kovacs, E. Benko, , B. Jones
This study shows BCL-XL antagonists reduce HIV in a cell model of latency but not in ex vivo reservoirs, suggesting resistance in true reservoir cells.
bioRxiv · Nov 25, 2020 · PreprintMicrobiology