Author

A. Bosque

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Macedo· 2 shared A. Chitrakar· 1 shared A. M. K. Weideman· 1 shared A. R. Coffey· 1 shared A. R. Ward· 1 shared A. Ward· 1 shared B. Jones· 1 shared B. Nguyen· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

A. Macedo

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Aminobisphosphonates reactivate the latent reservoir in people living with HIV-1

M. Sanz, A. M. K. Weideman, A. R. Ward, M. L. Clohosey, S. Garcia-Recio, S. R. Selitsky, B. T. Mann, M. A. Iannone, C. P. Whitworth, A. Chitrakar, C. Garrido, J. Kirchherr, A. R. Coffey, Y.- H. Tsai, S. Samir, , N. Soriano-Sarabia

This study shows that aminobisphosphonates reactivate latent HIV-1 in ART-suppressed individuals and activate immune effector cells, but do not significantly reduce the viral reservoir.

bioRxiv · Feb 7, 2023 · PreprintMicrobiology

The HIV latency reversal agent HODHBt enhances NK Cell effector and memory-like functions by increasing IL-15 mediated-STAT activation

A. Macedo, C. Levinger, B. Nguyen, M. Gupta, C. R. Cruz, K. Chiappinelli, K. Crandall, A. Bosque

This paper shows that HODHBt enhances NK cell effector and memory-like functions by boosting IL-15-mediated STAT activation, leading to increased cytotoxicity and cytokine secretion.

bioRxiv · Oct 14, 2021 · PreprintCell Biology

Selective BCL-XLAntagonists Eliminate Infected Cells from a Primary Cell Model of HIV Latency but not from Ex Vivo Reservoirs

Y. Ren, s. h. huang, A. Macedo, A. Ward, W. Conce, T. Klevorn, L. Leyre, D. Chan, R. Truong, T. Rohwetter, P. Zumbo, F. Dundar, D. Betel, C. Kovacs, E. Benko, , B. Jones

This study shows BCL-XL antagonists reduce HIV in a cell model of latency but not in ex vivo reservoirs, suggesting resistance in true reservoir cells.

bioRxiv · Nov 25, 2020 · PreprintMicrobiology