The structure, binding, and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3
D. Hall, B. D. Giaimo, S.-S. Park, W. Hemmer, T. Friedrich, F. Ferrante, M. Bartkuhn, Z. Yuan, F. Oswald, T. Borggrefe, J. Rual, R. Kovall
This paper defines the RBPJ-interacting domain of L3MBTL3 and reports the crystal structure of the RBPJ-L3MBTL3-DNA complex, revealing molecular interactions and functional consequences of mutations.
bioRxiv · Feb 9, 2022Biochemistry