Author

M. Bartkuhn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

B. D. Giaimo· 2 shared F. Ferrante· 2 shared F. Oswald· 2 shared R. Kovall· 2 shared T. Borggrefe· 2 shared T. Friedrich· 2 shared A. Borowek· 1 shared A. C. Joerger· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiophysics

B. D. Giaimo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease

S. Crnkovic, H. Thekkekara Puthenparampil, S. Mulch, V. Biasin, N. Radic, J. Wilhelm, M. Bartkuhn, E. Bonyadi Rad, A. Wawrzen, I. Matzer, A. Mitra, R. D. Leib, B. M. Nagy, A. Sahu-Osen, F. Valzano, , G. Kwapiszewska

The paper identifies disease-associated states in PASMC and PAAF from IPAH patients and identifies potential modulators of PASMC phenotypic transition.

bioRxiv · May 15, 2024Cell Biology

Effective in vivo binding energy landscape illustrates kinetic stability of RBPJ-DNA binding

D. Huynh, P. Hoffmeister, T. Friedrich, K. Zhang, M. Bartkuhn, F. Ferrante, B. D. Giaimo, R. Kovall, T. Borggrefe, F. Oswald, J. C. M. Gebhardt

The paper investigates RBPJ-DNA binding kinetics and cofactor interactions, finding that kinetic stability, not thermodynamic, governs target site specificity and that mutations affect both association and dissociation rates.

bioRxiv · Dec 19, 2023Biophysics

Functional diversity of the TP53 mutome revealed by saturating CRISPR mutagenesis

J. Funk, M. Klimovich, E. Pavlakis, M. Neumann, D. Drangenstein, M. Noeparast, P. Hunold, A. Borowek, D.-I. Balourdas, K. Kochan, N. Merle, I. Bullwinkel, M. Wanzel, S. Elmshauser, A. Nist, , T. Stiewe

This study uses CRISPR mutagenesis to analyze the functional impact of TP53 mutations across 9,225 variants, revealing their effects on tumor cell fitness and metastasis.

bioRxiv · Mar 10, 2023Cancer Biology

The structure, binding, and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3

D. Hall, B. D. Giaimo, S.-S. Park, W. Hemmer, T. Friedrich, F. Ferrante, M. Bartkuhn, Z. Yuan, F. Oswald, T. Borggrefe, J. Rual, R. Kovall

This paper defines the RBPJ-interacting domain of L3MBTL3 and reports the crystal structure of the RBPJ-L3MBTL3-DNA complex, revealing molecular interactions and functional consequences of mutations.

bioRxiv · Feb 9, 2022Biochemistry