Author

R. Kovall

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

B. D. Giaimo· 2 shared F. Ferrante· 2 shared F. Oswald· 2 shared M. Bartkuhn· 2 shared T. Borggrefe· 2 shared T. Friedrich· 2 shared D. Hall· 1 shared D. Huynh· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiophysics

B. D. Giaimo

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2 papers

Recent·Most cited

Effective in vivo binding energy landscape illustrates kinetic stability of RBPJ-DNA binding

D. Huynh, P. Hoffmeister, T. Friedrich, K. Zhang, M. Bartkuhn, F. Ferrante, B. D. Giaimo, R. Kovall, T. Borggrefe, F. Oswald, J. C. M. Gebhardt

The paper investigates RBPJ-DNA binding kinetics and cofactor interactions, finding that kinetic stability, not thermodynamic, governs target site specificity and that mutations affect both association and dissociation rates.

bioRxiv · Dec 19, 2023Biophysics

The structure, binding, and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3

D. Hall, B. D. Giaimo, S.-S. Park, W. Hemmer, T. Friedrich, F. Ferrante, M. Bartkuhn, Z. Yuan, F. Oswald, T. Borggrefe, J. Rual, R. Kovall

This paper defines the RBPJ-interacting domain of L3MBTL3 and reports the crystal structure of the RBPJ-L3MBTL3-DNA complex, revealing molecular interactions and functional consequences of mutations.

bioRxiv · Feb 9, 2022Biochemistry