Sirtuin 2 inhibition modulates chromatin landscapes genome- wide to induce senescence in ATRX-deficient malignant glioma
P. B. Malgulwar, C. Danussi, S. Dharmaiah, W. Johnson, A. Rao, J. T. Huse
This study shows that SIRT2 inhibition induces senescence in ATRX-deficient glioma models by altering chromatin landscapes and transcriptional profiles.
bioRxiv · Jan 9, 2023Cancer Biology