Author

D. Scadden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 2 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 5 Organism:mouse· 5 Assay:scRNA-seq· 4 Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

K. Gustafsson· 3 shared N. Baryawno· 3 shared N. Severe· 3 shared C. Rhee· 2 shared E. W. Scadden· 2 shared N. Barkas· 2 shared Y. Kfoury· 2 shared A. Chumber· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

K. Gustafsson

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer

K. Gustafsson, C. Rhee, V. Frodermann, E. W. Scadden, Y. Iwamoto, R. Palchaudhuri, S. L. Hyzy, A. E. Boitano, M. Nahrendorf, D. Scadden

This study shows that anti-CD45-ADC clears tissue-resident myeloid cells, enabling efficient replacement with donor cells and reducing atherosclerotic plaque burden.

bioRxiv · Sep 5, 2023 · PreprintImmunology

Predestined neutrophil heterogeneity in homeostasis varies in transcriptional and phenotypic response to Candida

A. K. Scherer, A. Hopke, S. Xu, A. Viens, N. J. Alexander, K. D. Timmer, D. Archambault, D. Floyd, N. J. Atallah, C. Rhee, M. Cetinbas, D. Scadden, D. Irimia, D. B. Sykes, R. I. Sadreyev, M. K. Mansour

The paper shows that clonal neutrophil progenitors have predestined transcriptional and epigenetic heterogeneity that influences their response to Candida infections.

bioRxiv · Nov 1, 2022 · PreprintImmunology

Thymic mesenchymal niche cells drive T cell immune regeneration

K. Gustafsson, S. Isaev, K. A. Kooshesh, N. Baryawno, K. D. Kokkaliaris, N. Severe, T. Zhao, E. W. Scadden, J. A. Spencer, C. Burns, K. Akilan, N. Barkas, H. Gessessew, C. P. Lin, P. V. Kharchenko, D. Scadden

This study identifies a thymic mesenchymal niche cell subset that supports T cell regeneration and shows its therapeutic potential in reversing thymic atrophy.

bioRxiv · Oct 12, 2022Immunology

Defocus Corrected Large Area Cryo-EM (DeCo-LACE) for Label-Free Detection of Molecules across Entire Cell Sections

J. Elferich, G. Schiroli, D. Scadden, N. Grigorieff

The paper introduces DeCo-LACE, a cryo-EM method for whole-cell section imaging, and uses 2DTM to map ribosome locations, enhancing visual proteomics.

bioRxiv · Jun 13, 2022Cell Biology

Immune-responsive biodegradable scaffolds for enhancing neutrophil regeneration

M. Kerr, D. McBride, W. Johnson, A. Chumber, A. Najibi, B. R. Seo, A. Stafford, D. Scadden, D. Mooney, N. Shah

This study develops a biodegradable HA cryogel scaffold that degrades in response to neutrophils, enhancing neutrophil recovery post-HSCT and accelerating cryogel degradation.

bioRxiv · Jan 21, 2022Bioengineering

Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment

N. Baryawno, Y. Kfoury, N. Severe, S. Mei, K. U. Gustafsson, T. Hirz, T. Brouse, E. Scadden, B. Choi, N. Barkas, J. Shin, P. Saylor, D. Scadden, D. Sykes, P. Kharchenko

The paper identifies an immunosuppressive microenvironment in human prostate cancer bone metastases and shows that disrupting the CCL20-CCR6 axis can restore T cell reactivity and improve survival in mice.

bioRxiv · Mar 19, 2020 · PreprintCancer Biology

A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia demonstrates cancer-crosstalk with stroma to impair normal tissue function

N. Baryawno, D. Przybylski, M. Kowalczyk, Y. Kfoury, N. Severe, K. Gustafsson, M. Francois, M. Tabaka, M. Hofree, D. Dionne, A. Papazian, D. Lee, O. Rozenblatt-Rosen, A. Regev, D. Scadden

The paper defines a cellular taxonomy of mouse bone marrow stroma using single-cell RNA-seq and shows how leukemia disrupts stromal function to impair normal hematopoiesis.

bioRxiv · Feb 21, 2019 · PreprintCell Biology