ImmunologybioRxivPreprint
Simultaneous, cell-intrinsic downregulation of PD-1 and TIGIT enhances the effector function of CD19-targeting CAR T cells and promotes an early-memory phenotype
Y. Lee, H. J. Lee, H. C. Kim…·C. H. Kim
This paper shows that simultaneously reducing PD-1 and TIGIT in CAR T cells improves their antitumor activity and memory phenotype in mouse models.
DOI 10.1101/2020.11.07.372334