Stable nebulization and muco-trapping properties of Regdanvimab/IN-006 support its development as a potent, dose-saving inhaled therapy for COVID-19
M. D. McSweeney, I. Stewart, Z. Richardson, H. Kang, Y. Park, C. Kim, K. Tiruthani, W. Wolf, A. Schaefer, P. Kumar, H. Aurora, J. Hutchins, J. M. Cho, A. J. Hickey, S. Y. Lee, S. K. Lai
This paper demonstrates that IN-006, a reformulated Regdanvimab, effectively traps SARS-CoV-2 virus-like particles in human airway mucus and achieves higher lung concentrations in rats when nebulized compared to intravenous delivery.
bioRxiv · Feb 27, 2022Bioengineering