Wanfeng Gong

The paper identifies multi-loop chromatin miswiring in FAD-mutant neurons that correlates with gene expression changes and DLX transcription factor activity.

This study shows that cohesin-mediated loops in G1 phase determine the genomic location of replication origins in S phase by anchoring replication initiation zones.

The paper shows that cohesin's role in neuronal gene expression depends on chromatin loop length, with longer loops requiring cohesin for full gene expression.

The paper shows that in fragile X syndrome, long-range heterochromatinization of distal synaptic genes with STR instability is reversible by overexpression of a pre-mutation-length CGG tract.

This paper introduces LADL, a light-activated system to dynamically control chromatin looping, showing it can redirect enhancer-promoter interactions and alter gene expression within four hours.

The paper introduces 5C-ID, a method that improves resolution and reduces noise in chromatin loop detection compared to standard 5C, enabling high-resolution 3D genome maps at lower cost than Hi-C.