Destabilization of intratumor Tregs by CTLA-4 engagement confers anti-CTLA-4-driven immunotherapy
Na Liu, Junji Xu, Wai Lim Ku, Weiwei Chen, Yaqiang Cao, Rida Kazmi, Wenwen Jin, Thierry Gauthier, Shunqun Luo, Song Shen, Liliana Catherine Patiño, Yun-Ji Lim, Valentina Ottaviani, Emily Naylor, Keji Zhao, WanJun Chen
This paper shows that anti-CTLA-4 antibodies destabilize intratumor Tregs via TGF-β signaling, enhancing anti-tumor immunity and immunotherapy.
bioRxiv · Aug 1, 2026 · PreprintImmunology