Cancer BiologyeLifePeer-reviewed
Punctuated mutagenesis promotes multi-stepevolutionary adaptation in human cancers
Christopher Graser, Wenbo Wu, Cole Christini…·Franziska Michor A
This study shows that punctuated mutagenesis in cancer enhances adaptation by facilitating crossing of fitness valleys through clustered mutations.
DOI 10.7554/elife.108058.3