Pharmacology & ToxicologybioRxivPreprint
NLX-112 is anti-inflammatory, upregulates GDNF and is neuroprotective against MPTP-induced nigrostriatal dopaminergic degeneration in mice
William H. Powell, Lucy E. Annett, Ronan Depoortère…·Mahmoud M. Iravani
This study shows NLX-112 protects against MPTP-induced dopaminergic neuron loss in mice by reducing microgliosis, increasing GDNF, and improving locomotor activity.