Author

X.-D. Wang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Assay:proteomics· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:drug response / drug discovery· 3 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Y. Yu· 5 shared C. Kim· 4 shared A. J. Berman· 1 shared A. K. Hollensen· 1 shared A.-D. Yang· 1 shared B. D. Fonseca· 1 shared C. Dajadian· 1 shared C. K. Damgaard· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersCancer Biology

Y. Yu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Induced Degradation of Lineage-specific Oncoproteins Drives the Selective PARP1 Inhibitor Toxicity in Small Cell Lung Cancer

C. Kim, X.-D. Wang, Y. Yu

This study identifies PARPi-induced degradation of lineage-specific oncoproteins as a mechanism for PARP1 inhibitor toxicity in SCLC, showing improved cytotoxicity when combined with targeted agents.

bioRxiv · Nov 2, 2022 · PreprintCancer Biology

Nimbolide Targets RNF114 to Induce the Trapping of PARP1 and Poly-ADP-Ribosylation-Dependent DNA Repair Factors

P. Li, Y. Zhen, C. Kim, H. Deng, H. Deng, X.-D. Wang, T. Qin, Y. Yu

This study identifies RNF114 as a key player in PARP1 trapping and shows that nimbolide blocks its degradation, enhancing PARP1 trapping and cytotoxicity in BRCA-deficient cancers.

bioRxiv · Oct 4, 2022Cancer Biology

Crosstalk between Proline Hydroxylation and Histidine Methylation Regulates Actin-Dependent Cell Mobility Control

Z. Liu, Z. Zi, C. Kim, X.-D. Wang, Y. Yu

This paper shows that proline hydroxylation and histidine methylation on actin regulate cell motility through a crosstalk mechanism involving PHDs, VHL, and SETD3.

bioRxiv · Aug 26, 2021 · PreprintBiochemistry

Quantitative Tyr Phosphoproteomic Analyses Identify Cholesterol as a Master Regulator of Tumor Adaptive Resistance to MAPK Inhibition

Y. Yu, X.-D. Wang, C. Kim, Y. Zhang, S. Rindhe, M. Cobb

bioRxiv · May 20, 2021 · PreprintCell Biology

LARP1 is a major phosphorylation substrate of mTORC1

B. D. Fonseca, J.-J. Jia, A. K. Hollensen, R. Pointet, H.-D. Hoang, M. R. Niklaus, I. A. Pena, R. M. Lahr, E. M. Smith, J. Hearnden, X.-D. Wang, A.-D. Yang, G. Celucci, T. E. Graber, C. Dajadian, , T. Alain

This study identifies LARP1 as a major phosphorylation substrate of mTORC1 and elucidates its role in regulating TOP mRNA translation.

bioRxiv · Dec 8, 2018 · PreprintBiochemistry