P. Li

Histone marks enable formation of immiscible phase-separated chromatin compartments

The paper shows that histone marks drive phase-separated chromatin compartments, influencing gene expression and cancer progression through the CBX7-PRC1 complex.

CLCC1 Governs Bilayer Equilibration at the Endoplasmic Reticulum to Maintain Cellular and Systemic Lipid Homeostasis

This study identifies CLCC1 as a key regulator of phospholipid trans-bilayer equilibration at the ER, essential for lipid homeostasis and preventing metabolic diseases.

Characteristics of JN.1-derived SARS-CoV-2 subvariants SLip, FLiRT, and KP.2 in neutralization escape, infectivity and membrane fusion

This study evaluates neutralization resistance, infectivity, and membrane fusion of JN.1-derived SARS-CoV-2 subvariants SLip, FLiRT, and KP.2, identifying key mutations affecting antibody sensitivity and spike function.

Beyond enumeration: Phenotype independent "labeling-capture-release" process enabling precise detection of circulating tumour cells and downstream applications

This paper introduces a labeling-capture-release method for isolating circulating tumor cells from blood samples with high efficiency and accuracy, enabling downstream applications.

Distinct Patterns of SARS-CoV-2 BA.2.87.1 and JN.1 Variants in Immune Evasion, Antigenicity and Cell-Cell Fusion

This study compares immune evasion, antigenicity, and cell-cell fusion properties of SARS-CoV-2 BA.2.87.1 and JN.1 variants, finding BA.2.87.1 shows less neutralization escape and higher infectivity than JN.1 and XBB.1.5.

Role of Hepatocyte RIPK1 in Maintaining Liver Homeostasis during Metabolic Challenges

This study identifies RIPK1 in hepatocytes as critical for maintaining liver homeostasis during metabolic challenges, showing its role in preventing inflammation and apoptosis in mice.

Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques

This study develops a HSV-vectored therapeutic vaccine that reactivates SIV latency and elicits immune responses, delaying viral rebound in SIV-infected macaques.

Vole genomics links determinate and indeterminate growth of teeth

This study identifies dental genes under positive selection in voles with different molar root structures, linking genetic changes to tooth growth patterns.

USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase transition potential

This study identifies USP10 as a novel regulator of β-catenin through dual mechanisms involving deubiquitination and phase separation, with implications for cancer treatment.

M1 Macrophage-Related Genes Model for NSCLC Immunotherapy Response Prediction

This study develops a model using M1 macrophage-related genes to predict immunotherapy response and prognosis in advanced NSCLC patients.

Sophocarpine inhibits TRP channels to produce anti-pruritic and analgesic effects in a mouse model of inflammatory itch and pain

This study shows that sophocarpine inhibits TRPA1 and TRPV1 channels, reducing itch and pain in a mouse model of inflammatory conditions.

Cellular protein painting for structural and binding sites analysis via lysine reactivity profiling with o-phthalaldehyde

This paper introduces RAPID-OPA, a method for intracellular protein labeling and structural analysis, identifying ligand-binding sites and conformational changes in cells.

Understanding the biosynthesis of human IgMs through a combinatorial expression of mutant subunits that affect different assembly steps

This study investigates IgM biosynthesis by analyzing mutant subunits affecting disulfide bonds, revealing the role of non-covalent interactions in IgM assembly and secretion.

PRO-LDM: Protein Sequence Generation with a Conditional Latent Diffusion Model

PRO-LDM generates protein sequences with tailored properties using a conditional latent diffusion model, enhancing diversity and design fidelity.

Pneumonic plague protection induced by a monophosphoryl lipid A decorated Yersinia outer-membrane-vesicle vaccine

This study develops a pneumonic plague vaccine using OMV46-LcrV, which shows reduced reactogenicity and complete protection in mice against Y. pestis challenge.

Molecular dynamics analyses of CLDN15 pore size and charge selectivity

The paper uses molecular dynamics simulations and cell culture experiments to study how the D55 residue in CLDN15 affects ion size and charge selectivity in tight junctions.

Global and local adaptation to aridity in a desert plant Gymnocarpos przewalskii

This study identifies genes involved in global and local adaptation to aridity in Gymnocarpos przewalskii, finding limited overlap between the two processes.

Central and peripheral clocks synergistically enhance circadian robustness, flexibility and performance of cardiac pacemaking

This paper develops a mathematical model to study how central and peripheral circadian clocks interact to regulate cardiac pacemaking in adult and aged mice, revealing their synergistic roles in maintaining circadian flexibility and performance.

BrrRCO, encoding a homeobox protein, is involved in leaf lobe development in Brassica rapa

This study identifies BrrRCO, a HD-Zip transcription factor, as a key gene regulating leaf lobe development in Brassica rapa, with cis-regulatory variations affecting its function and leaf shape.

A Phase Separation-Fortified Bi-Specific Adaptor for Conditional Tumor Killing

The paper designs modular ligands with phase-separation modalities to induce apoptosis in tumor cells through interreceptor clustering and conditional activation.

Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STINGA230 Variants

The paper characterizes BDW568, a non-nucleoside STING agonist, showing it activates STINGA230 variants in human cells and mimics endogenous ligands.

Genetic Screen Identified Prmt5 as a Neuroprotection Target against Cerebral Ischemia

This study identifies Prmt5 as a negative regulator of neuronal survival during cerebral ischemia and shows that its inhibition protects against neuronal death in a mouse model.

Uncovering Ghost Introgression Through Genomic Analysis of a Distinct East Asian Hickory Species

The paper detects ghost introgression in Carya sinensis using genomic analysis and phylogenetic methods, revealing introgression from an extinct lineage.

A Two-Filter Adaptation to Achieve Hemodiafiltration with Enhanced Performance

This paper adapts conventional HD machines to achieve HDF with improved urea clearance and comparable safety metrics.

Single-chain fluorescent integrators for mapping G-protein-coupled receptor agonists

The paper introduces SPOTIT and SPOTall sensors to detect GPCR agonist localization in the whole brain using fluorescent integrator sensors for multiple neuromodulators.

Structural principles of peptide-centric Chimeric Antigen Receptor recognition guide therapeutic expansion

This paper determines the structure of a peptide-centric Chimeric Antigen Receptor (PC-CAR) complex and identifies structural principles for antigen recognition across multiple HLA allotypes.

Ebola Virus Sequesters IRF3 in Viral Inclusion Bodies to Evade Host Antiviral Immunity

This study shows Ebola virus uses viral inclusion bodies to sequester IRF3, blocking type I interferon production and evading antiviral immunity.

Insight into the genetic diversity, resistance, and virulence of Listeria from the marine environment: reveal the risk of hypervirulent isolates

This study examines Listeria species in beach sand, identifying hypervirulent isolates and their potential role in human listeriosis.

Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2.

The paper identifies the T813S mutation in the S2 subunit of SARS-CoV Spike protein enhances fusogenicity by improving TMPRSS2 cleavage, increasing viral replication.

A Host-Harbored Metabolic Susceptibility of Coronavirus Enables Broad-Spectrum Targeting

The paper identifies a host metabolic pathway essential for coronavirus replication and shows that inhibiting it with Propranolol has broad antiviral effects.