Evolutionary BiologybioRxiv
Activation by Cleavage of the Epithelial Na+ Channel α and γ Subunits Independently Coevolved with the Vertebrate Terrestrial Migration
X.-P. Wang, D. M. Balchak, C. Gentilcore…·O. Kashlan
The paper shows that ENaC subunit cleavage sites coevolved with vertebrate terrestrial migration and lung development, enabling Na+ conservation and gas exchange.
DOI 10.7554/elife.75796