Kenneth H. Hu

The paper uses local gene editing in mouse tumor models to discover a novel fibroblast state and its impact on the tumor microenvironment.

The paper constructs an integrated atlas of tumor-infiltrating dendritic cells across species and immunotherapy conditions, revealing conserved activation states and spatial reorganization in response to therapy.

The paper identifies tetrads as a multicellular immune unit that correlates with antitumor immunity and response to checkpoint blockade in mouse and human tumors.

This study identifies Bhlhe40 as a key regulator of T cell effector differentiation, showing distinct roles in CD4 and CD8 T cells for anti-PD-1 and anti-CTLA-4 therapies.

This study shows that CD206+ macrophages support an anti-tumor network involving cDC1, NK cells, and CD8 T cells, and their depletion impairs tumor control in mice and correlates with poor survival in humans.

This study compares neoantigen vaccines and immune checkpoint therapies, finding they use distinct and overlapping mechanisms, with combined use showing superior efficacy.

The paper identifies space-time gene expression patterns in healing wounds and finds their conservation in tumors, revealing multicellular coordination and gene program activation.

ZipSeq maps single-cell transcriptomes in real-time within intact tissues, revealing new gene expression patterns and differentiation trajectories in various biological contexts.