NeurosciencebioRxivPreprint
An accumbal cholinergic ISR-HCN2 axis sustains maladaptive cue motivation
Shihao Huang, Jingliang Zhang, Yue Li…·Yan-Xue Xue
The paper identifies an ISR-HCN2 cholinergic mechanism in nucleus accumbens interneurons that sustains maladaptive cue-driven motivation and shows HCN blockade reduces cue-seeking behavior.
DOI 10.64898/2026.09.18.752826