Xianhong Yu

This study compares droplet-based single-cell sequencing platforms to help researchers select the most suitable one for their applications.

MobiChIP enables high-throughput single-cell ChIP-seq using droplets, integrating with scRNA-seq to reveal epigenetic and genetic heterogeneity in PBMCs.

The paper uses single-cell epigenomic tracing to study endothelial cell plasticity across mouse organs from development to aging.

The paper introduces CoTECH, a method for joint detection of chromatin occupancy and transcriptome in single cells, revealing epigenetic mechanisms in cell fate decisions.

CoBATCH enables high-throughput single-cell profiling of chromatin-binding proteins by combining combinatorial barcoding with targeted chromatin release, achieving high signal-to-noise and efficient epigenetic analysis.