Impaired astrocytic Cx43 syncytial network in lateral habenula affects synaptic connectivity and drives adolescent stress-induced depression
Hui Li, qi wang, Yixun Su, Hui Chen, Zhonghao Wu, Xiaoying Chen, Chenmeng Wang, Yafei Zhao, Dan Li, Xiaomin Huang, Rao Fu, Wenhui Huang, Yong Tang, Jianqin Niu, Alexei Verkhratsky, Chenju Yi
This study identifies impaired astrocytic Cx43 syncytial networks in the lateral habenula as a driver of adolescent stress-induced depression through disrupted synaptic connectivity and neuronal function.
bioRxiv · Oct 8, 2026 · PreprintNeuroscience