Author

Y. AlSaif

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. A. Carozza· 2 shared L. Li· 2 shared A. F. Cordova· 1 shared D. Fernandez· 1 shared G. Skariah· 1 shared J. A. Brown· 1 shared M. Smith· 1 shared R. E. Mardjuki· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

J. A. Carozza

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2 papers

Recent·Most cited

Probing pathophysiology of extracellular cGAMP with substrate-selective ENPP1

J. A. Carozza, A. F. Cordova, Y. AlSaif, V. Böhnert, G. Skariah, L. Li

This paper identifies a mutation in ENPP1 that selectively inhibits cGAMP degradation, enabling study of extracellular cGAMP's role in antiviral immunity and disease.

bioRxiv · May 4, 2021 · PreprintImmunology

Structure-aided development of small molecule inhibitors of ENPP1, the extracellular phosphodiesterase of the immunotransmitter cGAMP

J. A. Carozza, J. A. Brown, V. Boehnert, D. Fernandez, Y. AlSaif, R. E. Mardjuki, M. Smith, L. Li

This study develops small molecule ENPP1 inhibitors with sub-nanomolar potency and demonstrates their efficacy in delaying tumor growth in a breast cancer model.

bioRxiv · May 30, 2020Biochemistry