Author

A. F. Cordova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

L. Li· 4 shared C. Ritchie· 3 shared V. Böhnert· 2 shared G. Skariah· 1 shared G. T. Hess· 1 shared J. A. Carozza· 1 shared M. C. Bassik· 1 shared Y. AlSaif· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 17 mutual co-author links

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4 shared papersBiochemistry

L. Li

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Author profile →

4 papers

Recent·Most cited

ImmunologybioRxivPreprintMay 4, 2021

Probing pathophysiology of extracellular cGAMP with substrate-selective ENPP1

J. A. Carozza, A. F. Cordova, Y. AlSaif…·L. Li

This paper identifies a mutation in ENPP1 that selectively inhibits cGAMP degradation, enabling study of extracellular cGAMP's role in antiviral immunity and disease.

DOI 10.1101/2021.05.04.442665

mouseexperimental assay

𝕏 PostBluesky

Cancer BiologybioRxivApr 15, 2020

Human SLC46A2 is the dominant cGAMP importer in extracellular cGAMP-sensing macrophages and monocytes

A. F. Cordova, C. Ritchie, V. Böhnert, L. Li

The paper identifies SLC46A2 as the primary cGAMP importer in human monocytes and macrophages, revealing its role in cGAMP sensing and potential therapeutic applications.

DOI 10.1021/acscentsci.1c00440

humanmouse

𝕏 PostBluesky

BiochemistrybioRxivPreprintOct 18, 2019

In response to Luteijn et al.: Concerns regarding cGAMP uptake assay and evidence that SLC19A1 is not the major cGAMP importer in human PBMCs

C. Ritchie, A. F. Cordova, L. Li

DOI 10.1101/798397

humanbulk RNA-seq

𝕏 PostBluesky

BiochemistrybioRxivFeb 3, 2019

SLC19A1 is an importer of the immunotransmitter cGAMP

A. F. Cordova, C. Ritchie, G. T. Hess…·L. Li

The paper identifies SLC19A1 as the importer of cGAMP and other CDNs, revealing its role in activating the STING pathway and informing CDN-based cancer therapy development.

DOI 10.1016/j.molcel.2019.05.006

humangenetic perturbation / CRISPR

𝕏 PostBluesky