Identification of small molecule antivirals against HTLV-1 by targeting the hDLG1-Tax-1 protein-protein interaction
J.-C. Twizere, S. Maseko, Y. Brammerloo, I. Van.Molle, A. Sogues Castrejon, C. Martin, C. Gorgulla, J. Olivet, J. Blavier, T. Ntombela, D. Frank, H. Arthanari, H. Remaut, K. Salehi-Ashtiani, S. Ballet, O. Volkov
The paper identifies a small molecule that inhibits the Tax-1-hDLG1 interaction, reducing HTLV-1 cell-to-cell transmission in a T-cell model.
bioRxiv · Mar 15, 2023Biochemistry