Author

S. Ballet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Bioengineering· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 4 Organism:human· 4 Assay:protein structure· 2 Assay:proteomics· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. Steyaert· 3 shared W. Versees· 3 shared A. Wohlkonig· 2 shared B. Fischer· 2 shared C. Gorgulla· 2 shared C. Martin· 2 shared E. Pardon· 2 shared H. Arthanari· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBioengineering

J. Steyaert

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Identification and characterization of nanobodies acting as molecular chaperones for glucocerebrosidase through a novel allosteric mechanism

T. Dal Maso, C. Sinisgalli, G. Zilio, I. Tessari, E. Pardon, J. Steyaert, S. Ballet, E. Greggio, W. Versees, N. Plotegher

This study identifies nanobodies that act as molecular chaperones for glucocerebrosidase, improving its activity and stability, with potential therapeutic applications for Gaucher and Parkinson's diseases.

bioRxiv · Mar 25, 2024 · PreprintBiochemistry

Identification of small molecule antivirals against HTLV-1 by targeting the hDLG1-Tax-1 protein-protein interaction

J.-C. Twizere, S. Maseko, Y. Brammerloo, I. Van.Molle, A. Sogues Castrejon, C. Martin, C. Gorgulla, J. Olivet, J. Blavier, T. Ntombela, D. Frank, H. Arthanari, H. Remaut, K. Salehi-Ashtiani, S. Ballet, O. Volkov

The paper identifies a small molecule that inhibits the Tax-1-hDLG1 interaction, reducing HTLV-1 cell-to-cell transmission in a T-cell model.

bioRxiv · Mar 15, 2023Biochemistry

Nanobody CDR3 mimetics enhance SOS1-catalyzed nucleotide exchange on RAS

K. Van holsbeeck, B. Fischer, S. Gonzalez, C. Gadais, W. Versees, J. C. Martins, C. Martin, A. Wohlkonig, J. Steyaert, S. Ballet

This study shows that CDR3 mimetics can enhance SOS1-catalyzed nucleotide exchange on RAS, demonstrating functional modulation of protein-protein interactions through structural mimicry of a nanobody.

bioRxiv · Dec 9, 2022 · PreprintBioengineering

Competitive, connective and allosteric Nanobodies that modulate the SOS1-RAS protein-protein interactions and tune the nucleotide exchange rate as a starting point for drug design

B. Fischer, T. Uchanski, A. Sheryazdanova, S. Gonzalez, A. N. Volkov, E. Brosens, T. Zogg, V. V. Kalichuk, S. Ballet, W. Versees, A. A. Sablina, E. Pardon, A. Wohlkonig, J. Steyaert

The paper introduces methods to discover Nanobodies that modulate SOS1-RAS interactions and nucleotide exchange rates, with potential applications in drug design.

bioRxiv · Dec 6, 2022 · PreprintBioengineering

Structural basis for targeting the human T-cell leukemia virus Tax oncoprotein and syntenin-1 interaction using a small molecule

S. Maseko, I. Van Molle, K. Blibek, C. Gorgulla, J. Olivet, J. Blavier, C. Vandermeulen, S. Skupiewski, D. Saha, T. Ntombela, J. Lim, F. Lembo, A. Beauvois, M. Hamaidia, J.-P. Borg, , J.-C. Twizere

This study identifies the structural basis of Tax-1 interaction with syntenin-1 and demonstrates small-molecule inhibition of this interaction to target HTLV-1.

bioRxiv · Aug 25, 2021 · PreprintBiochemistry

Antimicrobial activity of a repurposed harmine-derived compound on extensively drug-resistant Acinetobacter baumannii clinical isolates

A. Breine, M. Van Gysel, M. Elsocht, C. Whiteway, C. Philippe, T. Quinet, A. Valcek, J. Wouters, S. Ballet, C. Van der Henst

The paper identifies a harmine-derived compound, HDC1, that inhibits growth of all tested extensively drug-resistant Acinetobacter baumannii isolates.

bioRxiv · Jun 30, 2021Microbiology