Author

Y. K. Im

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Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:metabolomics· 1 Approach:statistical model· 1

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C. Greenwood· 1 shared D. Avizonis· 1 shared G. Bridon· 1 shared I. Topisirovic· 1 shared J. St-Pierre· 1 shared J. Ursini-Siegel· 1 shared L. Hulea· 1 shared M. Cargnello· 1 shared

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2017-2017 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

C. Greenwood

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1 paper

Recent·Most cited

Cancer BiologybioRxivJul 8, 2017

Translational and HIF1α-dependent metabolic reprograming underpin oncometabolomeplasticity and synergy between oncogenic kinase inhibitors and biguanides.

L. Hulea, S.-P. Gravel, M. Morita…·I. Topisirovic

This study identifies translational reprogramming of non-essential amino acid synthesis and HIF1-dependent reductive glutamine metabolism as key factors enabling synergy between kinase inhibitors and biguanides in cancer cells.

DOI 10.1016/j.cmet.2018.09.001

humanmetabolomics

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