Author

J. St-Pierre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Blais· 1 shared B. Lacoste· 1 shared C. Greenwood· 1 shared C. Handschin· 1 shared C. O'Dwyer· 1 shared C. Pember· 1 shared D. Avizonis· 1 shared D. Woo· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperImmunology

A. Blais

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection

P. Ghorbani, S. Y. Kim, T. K. Smith, L. Minarrieta, V. Robert-Gostlin, M. K. Kilgour, M. Ilijevska, I. Alecu, S. A. Snider, K. D. Margison, J. R. Nunes, D. Woo, C. Pember, C. O'Dwyer, J. Ouellette, , M. D. Fullerton

This study shows that choline metabolism is essential for IL-4-induced macrophage polarization and RELMα expression during helminth infection, affecting immune homeostasis and parasite clearance.

bioRxiv · Sep 30, 2022 · PreprintImmunology

PGC-1α regulates mitochondrial calcium homeostasis, SR stress and cell death to mitigate skeletal muscle aging

J. F. Gill, J. Delezie, G. Santos, S. McGuirk, S. Schnyder, S. Frank, M. Rausch, J. St-Pierre, C. Handschin

This study shows that PGC-1α improves mitochondrial function and reduces sarcoplasmic reticulum stress and cell death in aging skeletal muscle, thereby delaying aging effects.

bioRxiv · Oct 23, 2018Cell Biology

Translational and HIF1α-dependent metabolic reprograming underpin oncometabolomeplasticity and synergy between oncogenic kinase inhibitors and biguanides.

L. Hulea, S.-P. Gravel, M. Morita, M. Cargnello, O. Uchenunu, Y. K. Im, S. McLaughlan, O. Larsson, M. Ohh, T. Ferreira, C. Greenwood, G. Bridon, D. Avizonis, J. Ursini-Siegel, J. St-Pierre, , I. Topisirovic

This study identifies translational reprogramming of non-essential amino acid synthesis and HIF1-dependent reductive glutamine metabolism as key factors enabling synergy between kinase inhibitors and biguanides in cancer cells.

bioRxiv · Jul 8, 2017Cancer Biology