Author

L. Hulea

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

A. A. Sow· 1 shared A. Anton· 1 shared A. Cotton· 1 shared A. Lamarre· 1 shared A. Obermayer· 1 shared A. Pichlmair· 1 shared B. Assaf· 1 shared C. Capdevielle· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperMicrobiology

A. A. Sow

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to Navitoclax

M. Neault, C.-E. Lebert-Ghali, M. Fournier, C. Capdevielle, E. A. R. Garfinkle, A. Obermayer, A. Cotton, K. Boulay, C. Sawchyn, K. H. Nguyen, B. Assaf, F. E. Mercier, J.-S. Delisle, E. A. Drobetsky, L. Hulea, , F. A. Mallette

This study identifies GLIS2 as a driver of pediatric AMKL and shows its sensitivity to navitoclax, offering a potential therapeutic strategy.

Cell Reports · Sep 1, 2023Peer-reviewedCancer Biology

Flaviviruses alter endoplasmic reticulum-mitochondria contacts to regulate respiration and apoptosis

W. Freppel, A. Anton, Z. Nouhi, C. Mazeaud, C. Gilbert, N. Tremblay, V. A. Barragan Torres, A. A. Sow, X. Laulhe, A. Lamarre, I. G. Rodrigue-Gervais, A. Pichlmair, P. Scaturro, L. Hulea, L. Chatel-Chaix

This study shows flaviviruses alter ERMCs to support viral replication and inhibit apoptosis.

bioRxiv · Mar 9, 2023 · PreprintMicrobiology

Translational and HIF1α-dependent metabolic reprograming underpin oncometabolomeplasticity and synergy between oncogenic kinase inhibitors and biguanides.

L. Hulea, S.-P. Gravel, M. Morita, M. Cargnello, O. Uchenunu, Y. K. Im, S. McLaughlan, O. Larsson, M. Ohh, T. Ferreira, C. Greenwood, G. Bridon, D. Avizonis, J. Ursini-Siegel, J. St-Pierre, , I. Topisirovic

This study identifies translational reprogramming of non-essential amino acid synthesis and HIF1-dependent reductive glutamine metabolism as key factors enabling synergy between kinase inhibitors and biguanides in cancer cells.

bioRxiv · Jul 8, 2017Cancer Biology