Antibodies set boundaries limiting microbial metabolite penetration and the resultant mammalian host response
Y. Uchimura, T. Fuhrer, H. Li, M. A. Lawson, M. Zimmermann, M. Gomez de Aguero, B. Yilmaz, F. Ronchi, M. Sorribas, S. Hapfelmeier, S. C. Ganal-Vonarburg, K. D. McCoy, U. Sauer, A. J. Macpherson
The paper develops a model to distinguish microbial and host metabolites using stable isotope tracing and shows that antibodies limit microbial metabolite penetration into host tissues.
bioRxiv · Sep 25, 2017Immunology