U. Sauer

Peroxiredoxinylation buffers the redox state of the proteome upon cellular stress

This study shows that peroxiredoxin Tsa1 in yeast peroxiredoxinylates hundreds of proteins, affecting metabolism and stress resistance, with thioredoxins removing the resulting disulfide bonds.

Long-term history dependence of growth rates of E. coli after nutrient shifts

This study shows that E. coli growth rates on carbon source combinations depend on prior growth conditions, persisting for 15 generations and involving the transcription factor Mlc.

Overall biomass yield on multiple nutrient sources

The paper quantifies how multiple nutrient sources affect bacterial biomass production, showing non-linear effects and introducing an extended model to capture these interactions.

Elevated arginine levels in liver tumors promote metabolic reprogramming and tumor growth

The paper shows elevated arginine levels in liver tumors drive metabolic reprogramming and tumor growth through feedback loops involving ASNS and arginase 1.

Distinct N and C cross-feeding networks in a synthetic mouse gut consortium

The paper maps cross-feeding networks in a synthetic mouse gut microbiota consortium, revealing distinct carbon and nitrogen metabolic pathways and their physiological benefits.

Ecological stochasticity and phage induction diversify bacterioplankton communities at the microscale

The paper investigates microscale microbial community dynamics on chitin particles, finding that stochastic processes and phage predation drive taxonomic and functional variability.

Dynamic metabolic exchanges between complementary bacterial types provide collaborative stress resistance

The paper studies metabolic interactions between bacterial species under acidification, showing how complementary metabolic strategies enable collaborative stress resistance and dynamic ecosystem behavior.

Hierarchical control of microbial community assembly

The paper shows specialized biopolymer degraders direct microbial community assembly through nutrient crossfeeding in a marine model system.

Integration of chemosensing and carbon catabolite repression impacts fungal enzyme regulation and plant associations

This study investigates how Trichoderma reesei senses glucose and regulates enzyme production and development in response to plant environments.

Niche partitioning facilitates coexistence of closely related gut bacteria

The paper shows that four Lactobacillus species coexist in the honey bee gut by partitioning pollen-derived resources, but not simple sugars, despite negative interactions.

Redox stress reshapes carbon fluxes of Pseudomonas putida for cytosolic glucose oxidation and NADPH generation

This study investigates how oxidative stress in Pseudomonas putida reconfigures carbon fluxes to enhance NADPH production and support redox stress responses.

A distinct growth physiology enhances bacterial growth under rapid nutrient fluctuations

This study shows that E. coli grown in fluctuating nutrient environments has a distinct physiology that reduces growth rate loss compared to steady environments with the same average nutrient concentration.

Bacterial glycogen provides short-term benefits in changing environments

This study shows glycogen in E. coli provides short-term metabolic benefits during rapid environmental changes by enabling quick carbon and energy access.

Host metabolic reprogramming of Pseudomonas aeruginosa by phage-based quorum sensing modulation

This study shows that phage LUZ19 modulates Pseudomonas aeruginosa quorum sensing by expressing Qst, which interacts with PqsD to reduce PQS metabolites, enabling successful infection.

Emergence of stable coexistence in a complex microbial community through metabolic cooperation and spatio-temporal niche partitioning

This study shows how kefir, a natural microbial community, achieves stable coexistence through spatio-temporal niche partitioning and metabolic cooperation during milk fermentation.

Synthesis and degradation of FtsZ determines the first cell division in starved bacteria

The paper shows that FtsZ synthesis and degradation determine the first division of starved bacteria in response to nutrient pulses.

Antibodies set boundaries limiting microbial metabolite penetration and the resultant mammalian host response

The paper develops a model to distinguish microbial and host metabolites using stable isotope tracing and shows that antibodies limit microbial metabolite penetration into host tissues.

Disentangling metabolic functions of bacteria in the honey bee gut

This study uses untargeted metabolomics to determine the metabolic contributions of individual bacteria in the honey bee gut microbiota, revealing independent metabolic niches and key roles in pollen digestion and host hormone production.