Author

A. J. Macpherson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 2 Assay:metabolomics· 2 Assay:metagenomics· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

B. Yilmaz· 2 shared A. De Sciscio· 1 shared A. J. Enright· 1 shared A. Parrish· 1 shared B. Blankenhaus· 1 shared B. H. K. Chan· 1 shared B. J. Ferguson· 1 shared B. Silva-Santos· 1 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersImmunology

B. Yilmaz

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mucin-degrading gut bacteria promote anti-parasitic immunity

M. Wolter, M. Boudaud, E. Grant, A. Parrish, A. De Sciscio, S. Thompson, J.-J. Gerardy, M. Mittelbronn, D. J. Thornton, A. J. Macpherson, R. K. Grencis, M. S. Desai

This study shows that mucin-degrading gut bacteria influence anti-parasitic immunity by modulating host immune responses, with dietary fiber affecting this interaction.

bioRxiv · Feb 28, 2022 · PreprintImmunology

Metabolic reconstitution by a gnotobiotic microbiota varies over the circadian cycle

D. Hoces, J. Lan, W. Sun, T. Geiser, E. Cappio Barazzone, M. Arnoldini, S. Nowok, A. J. Macpherson, B. Stecher, R. Zenobi, W.-D. Hardt, C. Wolfrum, E. Slack

This study shows that a gnotobiotic microbiota affects metabolic processes differently depending on the circadian cycle, influencing energy balance and substrate utilization.

bioRxiv · Sep 8, 2021Microbiology

Maternal γδ T Cells Shape Offspring Pulmonary Type-2 Immunity In A Microbiota-Dependent Manner

P. H. Papotto, B. Yilmaz, G. Pimenta, S. Mensurado, C. Cunha, G. J. Fiala, D. Gomes da Costa, N. Goncalves-Sousa, B. H. K. Chan, B. Blankenhaus, T. Carvalho, A. J. Macpherson, J. E. Allen, B. Silva-Santos

This study shows maternal γδ T cells influence offspring pulmonary type-2 immunity through microbiota-dependent mechanisms, affecting gut-lung axis development and inflammation.

bioRxiv · Aug 13, 2021Immunology

Smallpox vaccination induces a substantial increase in commensal skin bacteria that promote pathology and enhance immunity

E. V. Shmeleva, M. Gomez de Agüero, J. Wagner, A. J. Enright, A. J. Macpherson, B. J. Ferguson, G. L. Smith

This paper shows that smallpox vaccination with VACV increases skin commensal bacteria, which promote tissue damage but also enhance immunity and antibody responses.

bioRxiv · Jul 30, 2021 · PreprintMicrobiology

Antibodies set boundaries limiting microbial metabolite penetration and the resultant mammalian host response

Y. Uchimura, T. Fuhrer, H. Li, M. A. Lawson, M. Zimmermann, M. Gomez de Aguero, B. Yilmaz, F. Ronchi, M. Sorribas, S. Hapfelmeier, S. C. Ganal-Vonarburg, K. D. McCoy, U. Sauer, A. J. Macpherson

The paper develops a model to distinguish microbial and host metabolites using stable isotope tracing and shows that antibodies limit microbial metabolite penetration into host tissues.

bioRxiv · Sep 25, 2017Immunology