Author

Y.-S. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:proteomics· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

B. Dhayalan· 3 shared M. A. Weiss· 3 shared E. Meredith· 2 shared F. Ismail-Beigi· 2 shared J. T. Hinson· 2 shared K. Thakar· 2 shared R. Cohn· 2 shared Y. Yang· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiochemistry

B. Dhayalan

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Se-Glargine II. Native Function of a Basal Insulin Analog Stabilized by an Internal Diselenide Bridge

Y.-S. Chen, B. Dhayalan, Y. Yang, O. Weil-Ktorza, N. Metanis, M. A. Weiss

This paper describes an insulin analog with an internal diselenide bridge that maintains native function and stability, potentially improving insulin shelf life and accessibility.

bioRxiv · Jun 24, 2023 · PreprintBiochemistry

Stabilization of a Protein by a Single Halogen-Based Aromatic Amplifier

K. E. Hage, N. B. Phillips, Y.-S. Chen, B. Dhayalan, J. Whittaker, K. Carr, L. Whittaker, M. H. Phillips, F. Ismail-Beigi, M. Meuwly, M. A. Weiss

This study demonstrates that halogenation of an aromatic ring in insulin stabilizes the protein and enhances its resistance to fibrillation and biological activity.

bioRxiv · Jul 25, 2022Biochemistry

Age of diabetes onset in the mutant proinsulin syndrome correlates with mutational impairment of protein foldability and stability

B. Dhayalan, Y.-S. Chen, Y. Yang, M. Jarosinski, D. Chatterjee, R. Grabowski, S. Poordian, N. F. B. Phillips, P. Arvan, F. Ismail-Beigi, M. A. Weiss

The paper investigates how mutations at position B18 in proinsulin affect protein foldability and stability, correlating these effects with the age of diabetes onset in mutant proinsulin syndrome.

bioRxiv · Sep 24, 2021 · PreprintBiochemistry

Identifying cardiac actinin interactomes reveals sarcomere crosstalk with RNA-binding proteins

F. A. Ladha, K. Thakar, A. M. Pettinato, N. Legere, R. Cohn, R. Romano, E. Meredith, Y.-s. Chen, J. T. Hinson

The paper identifies cardiac actinin interactomes, revealing sarcomere crosstalk with RNA-binding proteins like IGF2BP2 that affect mitochondrial function and sarcomere assembly.

bioRxiv · Mar 18, 2020Cell Biology

A contraction stress model of hypertrophic cardiomyopathy due to thick filament sarcomere mutations

R. Cohn, K. Thakar, A. Lowe, F. Ladha, A. Pettinato, E. Meredith, Y.-s. Chen, K. Atamanuk, B. Huey, J. T. Hinson

This study uses CRISPR/Cas9 to create HCM iPSc models and finds that mutations cause hypercontractility and p53 activation linked to oxidative stress, suggesting p53 as a therapeutic target.

bioRxiv · Sep 4, 2018Cell Biology

Bloodstream Infection with Extended-spectrum Beta-lactamase-producing Escherichia coli: the role of virulence genes

W.-T. Hung, M.-F. Cheng, F.-C. Tseng, Y.-S. Chen, S. S.-J. Lee, T.-H. Chang, H.-H. Lin, C.-H. Hung, J.-L. Wang

This study investigates the association between virulence genes and outcomes in patients with bloodstream infections caused by ESBL-producing E. coli, finding specific gene and sequence type associations with mortality.

bioRxiv · Jul 10, 2018Microbiology

The effector TepP mediates the recruitment and activation of Phosphoinositide 3 Kinase on early Chlamydia trachomatis vacuoles

V. Carpenter, Y.-S. Chen, L. Dolat, R. Valdivia

This study identifies TepP as a Chlamydia trachomatis effector that recruits and activates PI3K on early vacuoles, modulating host signaling and gene expression.

bioRxiv · May 1, 2017Microbiology