T.-H. Chang

Structural basis of Norrin recognition by Lgr4/5/6

The paper determines the structure of Norrin bound to Lgr4ECD, showing conserved binding residues and overlapping binding sites with Rspo1 and Fz4CRD.

Structural insights into Frizzled assembly by acylated Wnt and Frizzled Connector domain

The paper reports structures of Frizzled domains complexed with acylated Wnt peptide, revealing different dimer conformations and interactions that inform Fz function modulation.

Chitin oligomers directly promote lymphoid innate and adaptive immune cell activation

This study shows chitin oligomers activate lymphoid innate and adaptive immune cells, including NK cells, B cells, and dendritic cells, through TLR2, expanding their role beyond myeloid cells.

Transkingdom mechanism of MAMP generation by chitotriosidase (CHIT1) feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing

This study identifies CHIT1 as an enzyme that converts fungal chitin into oligomers sensed by TLR2, revealing a mammalian MAMP generation system similar to plants.

Structure of the Shaker Kv channel and mechanism of slow C-type inactivation

The paper determines the structure of the Shaker Kv channel and reveals that slow C-type inactivation involves dilation of the selectivity filter.

Antibody Display of cell surface receptor Tetraspanin12 and SARS-CoV-2 spike protein

The paper develops an Antibody Display technology to graft proteins onto antibody CDR3 regions, demonstrating binding of Tspan12EC2 to Norrin and SARS-CoV-2 RBD to ACE2.

An all-solid-state heterojunction oxide transistor for the rapid detection of biomolecules and SARS-CoV-2 spike S1 protein

This paper develops an all-solid-state heterojunction oxide transistor for rapid, real-time detection of biomolecules and SARS-CoV-2 spike S1 protein at attomolar concentrations.

Degenerated virulence and irregular development of Fusarium oxysporum f. sp. niveum induced by successive subculture

This study shows that successive subculture of Fusarium oxysporum f. sp. niveum with aged mycelium leads to degeneration, reducing virulence through decreased cell wall-degrading enzyme activity and virulence gene expression.

Rapidly predicting vancomycin resistance of Enterococcus faecium through MALDI-TOF MS spectra obtained in real-world clinical microbiology laboratory

This study develops a machine learning algorithm using MALDI-TOF MS spectra to rapidly and accurately predict vancomycin resistance in Enterococcus faecium isolates, improving antibiotic use accuracy by 30%.

HDGF supports anti-apoptosis and pro-fibrosis in pancreatic stellate cells of pancreatic cancer

This study identifies the TGF-β1-activated CEBPD/HIF-1/HDGF axis in pancreatic stellate cells, showing HDGF promotes anti-apoptosis and pro-fibrosis, contributing to pancreatic cancer progression.

Altered Gene Regulatory Networks are Associated with the Transition from C3 to Crassulacean Acid Metabolism in Erycina (Oncidiinae: Orchidaceae)

This study compares gene regulatory networks between C3 and CAM species in Erycina to identify changes associated with the transition to CAM photosynthesis.

Bloodstream Infection with Extended-spectrum Beta-lactamase-producing Escherichia coli: the role of virulence genes

This study investigates the association between virulence genes and outcomes in patients with bloodstream infections caused by ESBL-producing E. coli, finding specific gene and sequence type associations with mortality.