NeuroscienceActa Neuropathologica CommunicationsPeer-reviewed
Correlative light and electron microscopy reveals that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease
Ya Zhou, Thomas R. Peskett, Christian Landles…·Helen R. Saibil
This study uses correlative light and electron microscopy to show that mutant huntingtin accumulates in endolysosomal organelles in presymptomatic Huntington's disease, altering endolysosomal homeostasis.