Author

Yan Ao

University of California, Los Angeles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Michael V. SofroniewiD· 4 shared Riki KawaguchiiD· 2 shared Shinong Wang· 2 shared Timothy Mark O’SheaiD· 2 shared Alexander L. WollenbergiD· 1 shared Alexander M. Bernstein· 1 shared Alice ZhangiD· 1 shared Alison GoateiD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersNeuroscience

Michael V. SofroniewORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Border-forming wound repair astrocytes

Timothy Mark O’Shea, Yan Ao, Shinong Wang, Yilong Ren, Amy L. Cheng, Riki Kawaguchi, Zechuan Shi, Vivek Swarup, Michael V. Sofroniew

The paper identifies the cellular origins and functional changes of astrocytes forming protective borders around CNS injuries, showing their role in neuroprotection.

Nature Neuroscience · Jun 21, 2024Peer-reviewedNeuroscience

Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration

Yuyan Cheng, Yuqin Yin, Alice Zhang, Alexander M. Bernstein, Riki Kawaguchi, Kun Gao, Kyra Potter, Hui-ya Gilbert, Yan Ao, Jing Ou, Catherine J. Fricano-Kugler, Jeffrey Louis Goldberg, Zhigang He, Clifford J. Woolf, Michael V. Sofroniew, , Daniel H. Geschwind

The paper identifies REST/NRSF as a suppressor of CNS axon regeneration using systems biology approaches and validates its role through genetic manipulations.

Nature Communications · Jul 29, 2022Peer-reviewedNeuroscience

Fine mapping of goat polledness variant in six Chinese native breeds

Yong Li, Tao Chen, Manman Yang, Han Hu, Dan jiang, Qiang Wei, Xingju Zhang, Yan Ao, Qingfeng Zhang, Zepu Miao, Ran Wang, Yuan-Lun Li, Sheng-Yu Chao, Lin Li, Tingting Zhang, Ming Fang

The paper identifies a structural variant associated with goat polledness through GWAS and CNV analysis, linking it to the ERG gene and providing insights into its molecular mechanisms.

bioRxiv · Dec 20, 2021 · PreprintGenetics

CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states

Kun Leng, Indigo V.L. Rose, Hyosung Kim, Wenlong Xia, Wilber Romero‐Fernandez, Brendan Rooney, Mark Koontz, Emmy Li, Yan Ao, Shinong Wang, Mitchell C. Krawczyk, Julia TCW, Alison Goate, Ye Zhang, Erik M. Ullian, , Martin Kampmann

The paper uses CRISPRi screens and single-cell transcriptomics in human astrocytes to identify regulators of inflammatory reactive states and their relevance in disease.

bioRxiv · Aug 23, 2021 · PreprintNeuroscience

Foreign body responses in central nervous system mimic natural wound responses and alter biomaterial functions

Timothy Mark O’Shea, Alexander L. Wollenberg, Jae H. Kim, Yan Ao, Timothy J. Deming, Michael V. Sofroniew

This study investigates CNS foreign body responses (FBRs) and shows they mimic wound responses, altering biomaterial functions based on interface properties.

Nature Communications · Dec 4, 2020Peer-reviewedNeuroscience