Lin Li

The RNA-binding protein TRIM71 Promotes Supporting Cell Reprogramming and Hair Cell Regeneration by Activating Sall4

This study shows TRIM71 promotes hair cell regeneration by reprogramming supporting cells and activating Sall4 in cochlear organoids and explants.

Lineage recording reveals hijacked hepatic progenitor states as a common origin of HCC and ICC

The paper uses CERAMIC to trace liver tumor initiation, identifying Hep_Bi-zonal cells as the origin of HCC and ICC and revealing peroxisomal metabolism and macrophage niches as key factors.

Single-cell profiling reveals MMP7-associated epithelial transition and immune-stromal remodeling in esophageal carcinogenesis

This study uses single-cell transcriptomics to identify MMP7-associated epithelial transitions and immune-stromal changes in esophageal carcinogenesis.

scBiopsy-seq: a platform for temporal single-cell RNA-seq analysis

scBiopsy-seq enables temporal single-cell RNA-seq analysis with high detection diversity and reliability, revealing key roles of fatty acid beta oxidation in transcriptional suppression.

Usefulness of scRNA-seq data in predicting plant metabolic pathway genes

This study uses scRNA-seq data with machine learning to predict plant metabolic pathway genes, finding higher accuracy compared to bulk RNA-seq and suggesting more benchmark genes improve predictions.

Fine mapping of goat polledness variant in six Chinese native breeds

The paper identifies a structural variant associated with goat polledness through GWAS and CNV analysis, linking it to the ERG gene and providing insights into its molecular mechanisms.