Hyosung Kim

This study shows that intermediate substrate stiffness promotes inflammation in human brain microvascular endothelial cells, which is reduced by fluid shear stress.

This study shows that IQGAP2 regulates immune cell entry into the CNS by modulating BBB function through adhesion receptors and antigen-processing machinery.

This study shows that amyloid-β exposure in astrocytes increases apo-transferrin levels, which enhances iron transport from endothelial cells at the blood-brain barrier, contributing to early iron accumulation in Alzheimer's disease.

The paper describes a method to engineer RNA-based biosensors for mammalian cells using random sequence libraries, demonstrating a biosensor for L-dopa detection.

The paper identifies 17β-estradiol and CAT-1 as regulators of leptin transport across an iPSC-derived blood-brain barrier model.

The paper uses CRISPRi screens and single-cell transcriptomics in human astrocytes to identify regulators of inflammatory reactive states and their relevance in disease.

This study shows that OLIG2 overexpression in Down syndrome patient-derived iPSCs leads to abnormal neurodevelopmental phenotypes, including impaired recognition memory in chimeric mice.

This study uses human pluripotent stem cell-derived cerebral organoids to show that oligodendrogenesis in the human brain has both ventral and dorsal origins, with dorsal cells dominating in fused organoids.