Yang Chen

This study identifies SPF1/2 SUMO proteases that inhibit seed filling and fatty acid biosynthesis by deSUMOylating WRI1, enhancing its degradation and reducing oil accumulation in Arabidopsis.

The paper shows that E. coli tRNASer3 can induce -1 frameshifting on GCA codons through doublet-decoding, revealing a mechanism involving A1493 and U36 interactions.

The paper develops two GPCR-specific models, DeepGPCR_BC and DeepGPCR_RG, for binary classification and affinity prediction of ligand interactions, achieving better performance than existing tools.

The paper identifies adeno-to-squamous transition (AST) as a mechanism of resistance to KRAS inhibitors in LKB1 mutant lung cancer and links KRT6A expression to poor patient outcomes.

This paper develops a scalable method to produce semiconductor biohybrids from wastewater pollutants for solar-to-chemical conversion, achieving 13 g/L of 2,3-butanediol in a 5-L fermenter with lower cost and CO2 emissions.

This study identifies Slc7a11's role in rabbit pigmentation and shows that POU2F1 regulates its expression to influence melanogenesis and apoptosis.

Structure-guided mutagenesis of GCaMP6 plus neuron-based screening yields a jGCaMP7 family, each variant tuned to a different regime: single spikes, neurites and neuropil, or population imaging.