Cancer BiologybioRxivPreprint
Decoupling Efficacy from Toxicity: Engineering Spatial Control in AAV-Mediated Gene Therapy
Ying Fan, Keqin Tan, Huan Chen…·Huapeng Li
This study shows that using tissue-specific AAV variants and local delivery reduces hepatic toxicity while maintaining therapeutic efficacy in gene therapy.
DOI 10.64898/2025.12.26.696588