Chen Wang

A Compact Regulatory Logic Governs Fibroblast Cell State Plasticity in Fibrosis

The paper identifies a compact regulatory logic governing fibroblast plasticity in fibrosis by analyzing enhancer repression and gene perturbations across multiple tissues.

Reformulating Protein Corona Prediction as Universal Protein-conditioned Learning

This paper introduces NanoPCT, a framework that predicts protein corona formation by learning universal patterns across proteins and enables zero-shot prediction for unseen proteins.

An AI-powered cloud biofoundry for autonomous biological research

The paper introduces iCloudBiofoundry, a cloud platform that autonomously designs, executes, and iteratively improves biological experiments using AI-driven workflows.

Recognition Mechanism of Serotonin by a G-Quadruplex-Duplex Hybrid Aptamer

This study determines the high-resolution NMR structures of Apt38, a truncated variant of the serotonin-binding aptamer, revealing its G-quadruplex-duplex hybrid structure and serotonin binding mechanism.

A patient-centric therapeutic paradigm uncouples prostate cancer suppression from systemic metabolic collapse

This paper identifies metabolic dysregulation caused by abiraterone in prostate cancer patients and develops Lifehug-9892 to suppress tumors while preserving systemic metabolic health.

Beyond point estimates: quantifying predictive uncertainty reveals hidden dimensions of biological age acceleration and improves risk interpretation

The paper develops a framework to quantify predictive uncertainty in biological age estimates, revealing hidden dimensions of aging and improving risk interpretation.

Striatal FOXP2 is essential for stable vocal production in non-human primates

This study shows that knocking down FOXP2 in the striatum of marmoset monkeys disrupts vocalization stability, revealing a role for FOXP2 in primate vocal production.

Volume regulation of cancer cells during osmotic pressure variation

This study compares how cancer and normal cells respond to osmotic pressure changes, finding cancer cells recover volume and traction forces more slowly under hypotonic conditions.

Chronic kidney disease exacerbates hyperlipidemia and atherosclerosis via miR-148a-3p targeting SIK1/AMPKα1 in liver

This study identifies miR-148a-3p as a key mediator of CKD-induced hyperlipidemia and atherosclerosis by targeting SIK1/AMPK1 in the liver via exosomal transfer.

The Mechanism of Vascular Endothelial Dysfunction Induced by Ferroptosis Mediated by NARFL Knockout

This study investigates NARFL knockout effects on vascular endothelial dysfunction through zebrafish, cell, and mouse models, identifying ferroptosis and oxidative stress as key mechanisms.

The Establishment of Transgenerational Epigenetic Inheritance in the C. elegans Germline is Mediated by Lipid Metabolism

This study shows that lipid metabolism, via Pod-2 and vitellogenins, mediates the establishment of transgenerational epigenetic imprints in C. elegans germline.

Comprehensive cross-population analysis of high-grade serous ovarian cancer supports no more than three subtypes

This study analyzes HGSC subtypes across populations and finds that three subtypes are consistently identified, while a fourth shows less robust cross-population similarity.