Ye Yu

Valine Engages a Prefrontal mGluR5 Allosteric Site to Preserve Social Behavior

The paper shows valine modulates mGluR5 in the prefrontal cortex to preserve social behavior through an allosteric mechanism.

An allosteric pocket in KV1.3 defines a distinct chemical space for immunomodulator design

The paper identifies a novel allosteric pocket in KV1.3 that enables selective immunomodulator design, revealing a non-contact selectivity mechanism through structural analysis and inhibitor development.

Cryo-EM elucidation of stoichiometric plasticity, asymmetric ligand recognition and allosteric coupling in human P2X2/3 heterotrimeric channels

The paper reports cryo-EM structures of human P2X2/3 heterotrimers in different functional states, revealing asymmetric ligand recognition and allosteric coupling mechanisms.

The DDIT4L-TOM40-ATP5A pathway suppresses glioblastoma oncogenesis

This study identifies DDIT4L as an inhibitor of glioblastoma by suppressing mitochondrial function and inducing apoptosis, with a synthetic peptide showing therapeutic potential.

Cryo-EM reveals the structural basis of subtype-specific, noncompetitive inhibition of the human P2X3 receptor

The paper reports the cryo-EM structure of the human P2X3 receptor complexed with sivopixant, revealing subtype-specific allosteric inhibition mechanisms and structural basis for improved selectivity.