Liang Chen

Defining nutrient dependencies of intestinal Klebsiella pneumoniae guides rational probiotic engineering

This study identifies nutrient dependencies of intestinal Klebsiella pneumoniae and develops a probiotic consortium to restrict its expansion.

Systematic evaluation of structural connectome thresholding in whole-brain network modelling

This study evaluates how thresholding structural connectomes affects whole-brain network models, finding that optimal sparsity depends on resolution and that tailored thresholding improves model performance.

BCIJelly: An integrated ecosystem for brain-computer interface research

BCIJelly provides a unified ecosystem for BCI research, standardizing data, integrating decoders, and enabling efficient deployment on neuromorphic hardware.

High prevalence of KPC-3 in carbapenem-resistant Pseudomonas aeruginosa across multiple clonal lineages in China

This study identifies a high prevalence of KPC-3 in carbapenem-resistant Pseudomonas aeruginosa isolates in China, showing clonal expansion and horizontal transmission across multiple lineages.

Heart rate dynamics embed a shared representation of individual brain organization and cognitive function

The paper links heart rate dynamics to brain functional organization and cognitive traits using multi-modal data and statistical analysis.

A curated human lactylome and protein language model framework enable accurate prediction and reveal local determinants of lysine lactylation

The paper introduces CLEAR-Lactyl, a curated dataset of human lysine lactylation sites, and AttentionKla, a deep learning model that accurately predicts lactylation sites and reveals sequence determinants.

A nitrite-responsive regulatory RNA locus sustains commensal resilience against nitrosative stress

This study identifies a nitrite-responsive regulatory RNA locus in Bacteroides thetaiotaomicron that enhances resilience to nitrosative stress during intestinal inflammation.

Decoding Immune Reconstitution Failure in People Living with HIV through Single-cell Genomics

This study uses single-cell multi-omics to analyze immune reconstitution failure in HIV patients, identifying genetic and epigenetic factors and developing a predictive model.

Human Lymph Node Cellular Senescence Atlas Reveals Age-Dependent Alteration in Germinal Center B Cell Function and Niches

This study maps age-related cellular senescence in human lymph nodes, identifying senescence markers and spatial shifts in germinal center B cells.

Kilohertz-rate two-photon voltage imaging of population dynamics in vivo

This paper introduces HS2PM, a two-photon microscope that enables kilohertz-rate imaging of neuronal populations in vivo, revealing voltage dynamics and their role in sensory adaptation and population coding.

A genome-wide CRISPR Screening identifies targets that drive Tolerogenic Dendritic Cells

This study uses CRISPR screening to identify molecular targets that drive the function of tolerogenic dendritic cells, revealing CD86 and UBE2L6 as key regulators of immune tolerance.

The DDIT4L-TOM40-ATP5A pathway suppresses glioblastoma oncogenesis

This study identifies DDIT4L as an inhibitor of glioblastoma by suppressing mitochondrial function and inducing apoptosis, with a synthetic peptide showing therapeutic potential.

Evaluation and application of chemical decrosslinking in the context of histopathological spatial proteomics

This study evaluates chemical decrosslinking to improve proteome coverage in FFPE tissues, finding that 3,4-diaminobenzoic acid enhances precursor identifications in pancreatic samples.

Single-Cell Proteomics of Human Peripheral Blood Mononuclear Cells Exceeding 600 Cells per Day

This paper develops a high-throughput single-cell proteomic method for PBMCs, achieving 660 cells per day with 750 protein identifications per cell and identifying low-frequency cell types.

Human DDIT4L intron retention contributes to cognitive impairment and amyloid plaque formation.

This study identifies DDIT4L intron retention (DIR) as a contributor to cognitive impairment and amyloid plaque formation in Alzheimer's disease through interactions with gelsolin and GluA1.

Roles and mechanisms of leptomeningeal collaterals in human distal MCA territory ischemia

The paper investigates the role and mechanisms of leptomeningeal collaterals in human distal MCA territory ischemia using experimental and computational methods.

Improving mRNA vaccine safety and efficiency with cationized lipid nanoparticle formula

This study modifies an mRNA-LNP vaccine formula with a cationic lipid to improve safety and efficiency, showing better immunogenicity and reduced off-target effects in mice.

Eukaryotic translation initiation factor eIF4E-5 is required for spermiogenesis in Drosophila melanogaster

This study shows that eIF4E-5 is essential for spermatid cyst polarization, individualization, and male fertility in Drosophila by regulating caspase activity and Soti localization.

Genome-wide identification of CDC34 that stabilizes EGFR and promotes lung carcinogenesis

This study identifies CDC34 as a critical E2 ubiquitin conjugase that stabilizes EGFR and promotes lung carcinogenesis by inhibiting its degradation.