Yi Sun

CAI-Vax: Computational Design of Personalized mRNA Cancer Vaccine Constructs After Antigen Selection

CAI-Vax designs personalized mRNA cancer vaccines by optimizing antigen sequences based on HLA compatibility, reducing predicted junctional binding while varying performance across prediction models.

LARP4 is a B cell-specific metabolic checkpoint for plasma cell differentiation and a therapeutic target in systemic lupus erythematosus

BMSC-Laden PEGDA/HAMA Dual-Crosslinked Hydrogels with Distinct Stiffness Profiles for Osteochondral Defect Repair

This study develops a BMSC-laden PEGDA/HAMA hydrogel with distinct stiffness profiles to repair osteochondral defects, showing improved defect filling and subchondral bone remodeling in vivo but limited collagen type II expression.

A generalizable system for antigenic peptide targeting across HLA-I allotypes

The paper develops a system to create binders compatible across HLA allotypes, validated against clinically relevant antigens and demonstrated in CAR T cells.

MERFISH 2.0, an ultra-sensitive single-cell spatial transcriptomics imaging chemistry across diverse tissue types

MERFISH 2.0 improves transcript detection sensitivity in degraded and archival tissues, enhancing spatial transcriptomic analysis of human and mouse samples.

Design of solubly expressed miniaturized SMART MHCs

This paper designs soluble, miniaturized MHC proteins that enable stable expression in E. coli and retain peptide and TCR binding specificity.

Carbon monoxide exposure stimulates growth and activity of primary producers in diverse soil ecosystems

This study shows that carbon monoxide exposure promotes growth and activity of carboxydotrophic bacteria in diverse soil ecosystems, suggesting a potential role for soils as a CO sink.