Tong Zhang

The paper identifies a novel biosynthetic pathway for baccatin III production using engineered microbes, achieving its complete de novo synthesis through enzymatic validation and pathway engineering.

This study identifies the complete biosynthetic pathway of camptothecin, discovers missing enzymes, and validates the pathway through heterologous reconstruction in yeast.

This study shows that H2A.Z's sequence-encoded flexibility in specific regions enhances DNA unwrapping and enables SUV420H1 recognition, revealing a mechanism linking nucleosome dynamics to epigenetic enzyme specificity.

This study identifies halomethanes as potential substrates for HgcAB, suggesting their role in the evolution of mercury methylation through metabolic dehalogenation.

MERFISH 2.0 improves transcript detection sensitivity in degraded and archival tissues, enhancing spatial transcriptomic analysis of human and mouse samples.

The paper identifies a mutation in PIKFYVE as a cause of congenital cataract and shows that Baf-A1 treatment alleviates the defect in zebrafish models.

The paper analyzes genomic data from pancreatic neuroendocrine tumors to identify a widespread copy neutral loss-of-heterozygosity pattern linked to tumor progression and potential therapeutic targets.

The paper examines lipid transitions in giant panda milk from colostrum to mature milk, finding an early provision of signaling lipids followed by a shift to energy-provisioning lipids.

This study analyzes changes in the milk metabolome of giant pandas over early lactation, identifying three phases and individual differences, with implications for neonatal development.