Hua Bai

This paper designs soluble, miniaturized MHC proteins that enable stable expression in E. coli and retain peptide and TCR binding specificity.

This paper evolves computationally designed protein binders using in vivo hypermutation and maps their sequence-affinity landscapes to understand affinity improvements and mutation interactions.

This paper designs a tunable protein filament that assembles in response to a peptide ligand and demonstrates its polarized growth and nucleation mechanisms.