Yi Xie

An architectural switch in the evolution of the γ-tubulin ring complex

This study presents the cryo-EM structure of the C. elegans γ-TuRC, revealing how it templates 11-protofilament microtubules through a divergent 4-spoked assembly.

Combinations comprising dual β-lactams and a β-lactamase inhibitor achieve optimal synergistic inhibition of Mycobacterium abscessus growth

This study shows that combinations of dual β-lactams and β-lactamase inhibitors synergistically inhibit Mycobacterium abscessus growth, challenging the traditional view of their mechanisms.

A Multi-Region Brain Model to Elucidate the Role of Hippocampus in Spatially Embedded Decision-Making

The paper presents a multi-region brain model to study how hippocampal circuits contribute to spatial decision-making, finding that a specific architecture optimizes learning and matches experimental data.

Activity-dependent synthesis of Emerin gates neuronal plasticity by regulating proteostasis

The paper identifies Emerin as an activity-induced protein that gates neuronal plasticity by inhibiting protein synthesis and altering dendritic spine morphology.

Phosphorylation of pyruvate dehydrogenase marks the inhibition of in vivo neuronal activity

The paper identifies phosphorylated pyruvate dehydrogenase (pPDH) as an in vivo marker for neuronal inhibition, correlating with reduced action potential firing and detectable across various inhibitory conditions.