Hugo Muñoz-Hernández

This study presents the cryo-EM structure of the C. elegans γ-TuRC, revealing how it templates 11-protofilament microtubules through a divergent 4-spoked assembly.

This study uses cryo-EM to resolve microtubule structures in different nucleotide states, revealing how GTP hydrolysis affects lattice stability and microtubule dynamics.

The paper introduces MiCSPARC, a cryo-EM pipeline for microtubule structure determination, achieving high-resolution reconstructions of decorated and undecorated microtubules.

This study presents the cryo-EM structure of the R2C complex, revealing how CCDC103 interacts with RUVBL1-RUVBL2 to facilitate dynein motor assembly in PCD.

This paper reports cryo-EM structures of NEDD1 bound to the human γ-TuRC with and without CDK5RAP2, revealing how NEDD1 anchors the complex and orients its microtubule-binding domains.

This study determines the structure of the gamma-tubulin ring complex (gamma-TuRC) activated by CDK5RAP2 and shows how it promotes microtubule nucleation by closing the gamma-tubulin ring.